The whole towns sleeping Essay Example

The entire towns dozing Paper All through this paper I mean to investigate the viability of the diverse account styles utilized in the two short stories, A Terribly Strange Bed and The Whole Towns Sleeping. The narratives were expounded on one hundred years separated, The Whole Towns Sleeping in 1950 and A Terribly Strange Bed, a lot prior in 1856. This implies not exclusively will the depiction of the tales change dependent on the individual styles of composing of the writers yet in addition the social history of the hours of composing will be very extraordinary. A Terribly Strange Bed is a story written in the principal individual account, which implies it is composed as an individual record of the occasions inside the story from the perspective of the primary character. It is typically composed as a character reviewing the story to another person after the occasions have occurred. The Whole Towns Sleeping then again is a story written as an outsider looking in account which implies it is composed from the perspective of an imperceptible observer who has no impact in the genuine story. It is composed as the occasions occur and is a lot of like a fly on the divider sort of point of view. The layout of the story in The Whole Towns Sleeping is that there is a quality of strain working in a humble community as a man nicknamed the forlorn one is circumventing murdering ladies But the others choked four of them, their tongues standing out of their mouths, they state. The fundamental subject of the story is about the responses and sentiments of three lady women as they stroll through the town in the corner of night to visit the film. We will compose a custom article test all in all towns dozing explicitly for you for just $16.38 $13.9/page Request now We will compose a custom article test in general towns dozing explicitly for you FOR ONLY $16.38 $13.9/page Recruit Writer We will compose a custom article test in general towns dozing explicitly for you FOR ONLY $16.38 $13.9/page Recruit Writer The pressure and dread of the story is expanded as the ladies discover the body of a companion who has been missing, Eliza Ramsell, and their reaction isn't to come back to the wellbeing of their homes, however is to proceed with their arrangements to stroll on, to the film. The women even mock the counsel of the police to get back following the film appearing and wind up strolling through the town at 12 PM when about the various inhabitants are securely secured up their homes snoozing. The peak of the story comes when the women need to separate as they arrive at their individual homes and Lavinia Nebbs is left to walk the most recent five minutes alone through the profound, profound and dark, dark gorge. The story closes with a wind as Lavinia at last arrives at the wellbeing of being inside her home. A Terribly Strange Bed is an anecdote about a card shark who visits, as rogue a spot, by all regard, as you ought to ever wish to see. This is a grimy betting house where the subject of the story has an astounding run of good karma and is sufficiently blessed to use up every last cent. While playing he is become a close acquaintence with by a fairly dubious example of an old warrior. This trooper later gets the subject alcoholic and leads him to a room where the horribly bizarre bed is arranged. As the subject attempts to rest he becomes mindful that the bed he is lying on is shutting downward on him, taking steps to choke out him. He just figures out how to escape with his life, by moving from the moving bed and going out by means of his window and afterward descending a water pipe into the road beneath. The plots of the two stories are very extraordinary yet the subjects of making an air of dread and pressure are fundamentally the same as. In the two stories there is a hero who is overbearing and who is comrade of themselves and the moves that they take. They don't tune in to their friends and dont acknowledge counsel quite well. Be that as it may, the strain of the two stories is created in very various styles. In The Whole Towns Sleeping there is a moderate collection of numerous occasions each adding to the pressure before the peak is arrived at when Lavinia, the hero, crosses the gorge. Conversely, in A Terribly Strange Bed there isnt as much develop of pressure and less occasions occur before the second when the rival endeavors murder on the hero. Be that as it may, there is a more noteworthy utilization of language and lingo making the story as long as The Whole Towns Sleeping, yet less occupied. From the very beginning there are pieces of information regarding what the tales are around, A Terribly Strange Bed begins to assemble an upsetting climate with an itemized portrayal of the betting house which the hero and his companion visit. Expressions like,here there was only catastrophe and the exhibition was something to sob over, proposes an ideal setting for damage to come upon the character. The utilization of these expressions in the principal individual shows both supposition and feeling. This is a successful method of laying the right foundation in light of the fact that a picture of a filthy, faintly lit live with seriously dressed, bristly tramps sitting and inclining toward dividers is promptly tossed into the brain of the peruser, making a feeling of anxiety. In The Whole Towns Sleeping the main trace of dread is recommended by the title of the film the women are to go to Welcome, Danger!

Fact Essay Topics - How to Choose the Best Topic For Your Final Project Essay

Fact Essay Topics - How to Choose the Best Topic For Your Final Project EssayWhen writing a final fact essay it is important to make sure that the topic of the final project is unique. There are some topics which will suit different people and there are others which are suited for certain groups of people. What this means is that you will need to look at the topic you want to write about carefully.It is possible to search for topics, but what many students find really helpful is the use of online forums. The more information you have on a particular topic the better chance you have of writing the best possible fact topic. It also means that it is easier to write if you know what the topics are first. This way you will be sure to give a unique and personal essay.You will need to have an idea of what the topic of the final project will be before you start to write. This is vital because the topic you choose will influence the type of the final project. This can be as simple as choosing a different theme or going with a different subject. However, there are other factors too, which will affect the project including the theme, author and submitter, length of time, etc.You can think about whether you want to focus on one aspect of the project or whether you want to combine a few aspects into one project. For example, you may decide to focus on a particular author. This can be a great idea if you have already read a number of his books or if you have already read a number of his articles. However, if you want to tackle a more general topic, you may have to write a number of essays, which should still tell a relevant and personal story.There are various methods that you can use to choose the best fact topic. Some of these include finding out as much information as possible about the topic you are thinking of writing about. Using an internet search engine to help you locate the information you need is a good starting point. By using an article directory, you can be sur e to get as much information as possible, including the topics and authors you want to write about.Some other methods include going through forums or blogs related to the topic you are considering writing about. Again, you can find out about the subjects and authors you wish to write about by using an internet search engine. By doing this you can create a list of the topics that you have chosen. Using this list as a basis, you can now go back and look at the articles and web content, which deal with that topic, and begin writing your own project around those topics.It can be very useful to talk to people who have worked on a project which is similar to yours. By talking to other students or members of staff, you can get ideas that will improve your project. This could be in the form of writing a blog post, or offering to help them with the submission process. This will allow you to choose the best topic and to make sure that the final project has all the information that you need.

The Roman Empire Essay - 2154 Words

Kevin Paltoo EUH 1000 Mr. Rogers 04/10/2010 The Lex Oppia was a law established in ancient Rome in 215 BC, at the height of the Second Punic War during the days of national catastrophe after the Battle of Cannae. This law was designed to limit the rights of women. The law was also passed to tap into wealthy women fortunes by the state in order to pay for the costs of the war. This law basically stripped the rights of women. Marcus Porcius Cato also known as the censor is one of the statesmen that supported the Lex Oppia law. Marcus Porcius Cato was one of the statesmen who reject repealing the Lex Oppia law. Cato stated â€Å" If each of us, citizens, had determined to assert his rights and dignity as a husband with respect to his own†¦show more content†¦The Romans were more interested in practical matters of law, governance, and military strategy than they were in philosophy and art. But for Cicero to really use philosophy effectively, he needed to make it accessible to a Roman audience. He did this in part by translating Greek works into Latin, including inventing Latin words where none seemed suitable for Greek concepts (including the Latin words which give us the English words morals, property, individual, science, image, and appetite), and in part by drawing on and idealizing Roman history to provide examples of appropriate conduct and to illustrate the arguments of philosophy. He also summarized in Latin many of the beliefs of the primary Greek philosophical schools of the time. Cicero grew up in a time of civil unrest and war. Sulla’s victory in the first of many civil wars led to a new constitutional framework that undermined liberty which was the fundamental value of the Roman Republic. Nonetheless, Sulla’s reforms strengthened the position of the equestrian class, contributing to that class’s growing political power. Cicero undermined his efforts in preserving the Roman constitution as which he felt was being contaminated by optimates. The consequence of this was that Cicero was exile from Rome because of these actions. Tiberius Gracchus was a Roman politician. As a plebeian tribune, his reforms of agrarian legislation caused political turmoil in the Republic.Show MoreRelatedThe Roman And Roman Empire1068 Words   |  5 PagesThe Roman Empire, which was centered in the city of Rome, was the most extensive western civilization of ancient times. With its major advancements and prosperity it is hard to believe that the Roman Empire suddenly collapsed and fell into a time known as the Dark Ages. After a period of struggles for the Roman E mpire, the empire gradually fell. Rome was the most successful civilization of its time. Its strategic location in the center of the Italian Peninsula and the fertile plains that supportedRead MoreThe Roman Of Roman Empire Essay1234 Words   |  5 Pages The Roman scutum was a large body shield used in battles, sieges, and gladiator fights. The scutum was used from the early Roman Republic until the third century CE and helped to define many of the Roman battle tactics that made them so successful. The curved, semi-cylindrical design provided full-body protection and was especially used in the testudo formation during sieges. The Roman Scutum is a perfect example of the military genius of the Roman Legion. The Roman Empire was created from theRead MoreThe Roman Empire1469 Words   |  6 Pagesthe Roman Empire. The Roman way of life and â€Å"Pax Romana† set up a standard of what defined civilization great. However, what was it that made the Roman life great? Was it the rules, the system of government, the virtues of the people? I believe what made the Romans so mighty was a blessing from God due to the outpouring revival of their hearts. However, to fully understand how their hearts were revived for Christ and how God had His hand on them we must take a look at the past of the Romans AfterRead MoreRoman Empire871 Words   |  4 PagesThe Roman Empire is known as one of the greatest empires of all time, blossoming politically, economically, and culturally. Rome was quickly expanding, reaching as far as North Africa. When Octavian came into power, the Pax Romana, or â€Å"Roman Peace,† began. However, this long peace may have triggered the beginning of the end of the Roman Empire. Because Rome was not distracted by conquering foreign lands, its citizens relaxed and lived in luxury. There did not seem to be any goals they did notRead MoreThe Roman Empire And The Romans1815 Words   |  8 PagesIn Roman history, it is often true that history was written by the victors, and given the large expansion of the Roman Empire, the Romans likely wrote over the accounts of the civilizations they took over, adapting the new provinces into their way of life and assimilating Roman culture into new facets of outlying territories way of life. The Roman Empire and Aug ustus had the ambition to expand north, going east of the Rhine where they had never gone, to take over new territory and the tribes thatRead MoreThe Roman Empire1551 Words   |  7 PagesStep 1: Plan What kind of technology in the Roman Empire affect its growth the most? I will be investigating from the start of the Roman Empire in 753 BCE to when the Western Roman Empire fell in 476 CE. This investigation will have a broad scope while investigating and include things from the Roman Legion to aqueducts and concrete. This investigation will not include technology that was not widely used to better the Roman Empire. The research question will answer my question by conducting researchRead MoreThe Roman Empire Essay1697 Words   |  7 Pages The Roman Empire, arguably one of the greatest civilizations to have ever ruled here on earth. The story is that it was founded by two brothers, Romulus and Remus, sons of Mars, the God of war, and raised by a she-wolf. After killing his brother for crossing his wall, Romulus went on to become the first king of Rome, which was named for him. Later when the men of Rome wanted noble women to be the mothers of their children, they conceived of a plan that included deceiving the Sabin’s and kidnappingRead MoreThe Roman Empire912 Words   |  4 PagesPaper B To many people, the mention of the Roman Empire invokes thoughts of gladiators, debauchery, and the abuse of power. To others, it brings visualizations of classic statues, beautiful temples, and mythological gods. The Roman Empire was all of that and more. The saying, â€Å"Rome wasn’t built in a day† is true and its fall and decline happened gradually as well. Ancient Rome has inspired volumes of historical works, theatrical plays, and even movies in more recent times. More specifically,Read MoreThe Roman Empire Essay1216 Words   |  5 Pagesvictory. Romulus’s story influenced many Romans but, what really happened was Romans were under Etruscan rule for many years as slaves until the Romans rebelled and overthrew their masters. Romans were discouraged by Greece thinking Rome would be easily swept away. Rome was attacked by many barbaric tribes including fighting a war with the Etruscans but triumphed again and again. Rome started with nothing and worked it s way to the top, as nothing could break the Roman spirit, and their drive to dominateRead MoreThe Roman Empire903 Words   |  4 PagesOne of the greatest empires in history is the Roman Empire, but ironically what makes it one of the greatest is also what lead it to start falling apart. In other words, many different factors lead Rome to its success and prosperity, but these factors also are the ones that initialize the ruin of the republic. Different authors such as Polybius, Cicero, Sallust and Plutarch describe several of these factors that lead the Roman Empire to its glory and failure. Polybius relates Rome’s success to its

Individual Moralities, Social Responsibilities and...

In the essay by J.S. Mill, â€Å"Of the Limits to the Authority of Society over the Individual,† he claims that â€Å"No person ought to be punished for simply being drunk†¦Ã¢â‚¬  In the build up to this conclusion, he offers several explanations for his reasoning, which include individual morality and responsibility, public interference and establishing precisely where authority over an individual beings for the society. As an individual within a society, you become obliged to follow certain codes of conduct, regardless of your own individual morals. To maintain a harmonious balance within a society, each person must behave within a certain code of conduct towards the rest of the individuals and the society as a whole. Although the â€Å"code† does not ask individuals to change their own morals, it does ask that they not injure the interests or rights of others. One must also realize that their morals may differ from that of another individual. Although they may practice their right of freedom by living according to their own morals and beliefs, they must still attempt to live within this social code of conduct. Furthermore, it becomes the responsibility of one’s self to ensure they are respecting the benefits given to them as a part of the society. As Mill says, â€Å"Everyone who receives the protection of society owes a return for the benefit.† (16) This can be achieved in various ways, such as returning good deeds, and acting in good faith towards the society. Unfortunately, it is often muchShow MoreRelatedSources of Ethics20199 Words   |  81 PagesSubpoenas or Other Legal Process 98 XII. DISCIPLINARY ACTION AND VIOLATIONS OF THE CODE 98 XIV. APPLICATION/WAIVERS 100 XV. TO REPORT AN ETHICS VIOLATION 101 2.63- Many professional and industries association’s code of ethics: 102 RESPONSIBILITIES OF A PROFESSIONAL: 102 3.0- CONCLUSION: 105 4.0-REFFERENCES 106 1.0- JOHN STEINER AND GEORGE STEINER SIX PRIMARY SOURCES OF ETHICS: Six primary sources have been identified in the American business area by ethics scholarsRead MoreLogical Reasoning189930 Words   |  760 Pagesenough reasons. You applied this principle when you asked Juanita why she thought it best to leave. Similarly, if you expect people to accept your own conclusion, then its your responsibility to give them reasons they can appreciate. If you expect people to accept your own conclusion, then its your responsibility to give them reasons they can appreciate. Lets examine that last remark. A conclusion backed up by one or more reasons in any order is called an argument, even when the reasoner

Irony of Earthly Power Essay Example For Students

Irony of Earthly Power Essay People live life wanting everything they cant afford. Millions of Americans idealize famous movie actors and musicians, and wish to aspire to that degree of wealth. Many people are envious of such billionaires as Bill Gates, and tell themselves they could have done that. Everyone wants to be rich. They feel that if they had all the money they wanted, they could truly be happy. The truth is that money and riches really dont bring anyone an unsurpassable or measureless amount of happiness. For example, winners of the Powerball lottery game may seem to have found happiness, but on a recent Oprah show they told of their extreme depression, and even the debt that money cost them. In fact, being rich or powerful brings just the opposite of happiness. It brings depression, and a legacy of nothingness. One example of this is seen in Percy Bysshe Shelleys Ozymandias. A traveler was talking with the speaker of the poem, and describing his recent journey to an antique land. (1)1 The traveler tells of a statue, erected for the King2. But now, that statue is half sunk, a shattered visage lies . (4) Clearly, the King the statue was created for no longer reigns, neither here on earth nor in human minds. In Shelleys poem, the traveler describes the characteristics of the King very well, and implies his unhappiness. whose frown,/and wrinkled lip, and sneer of cold command (4-5) could only be attributes of a deeply unhappy man. Even power over slaves did not delight him. The hand that mocked them, and the heart that fed (8) on the toils of the slaves did not bring him joy. The King may have been powerful, but that power evidently did not bring him pleasure. Perhaps the greatest proof that riches and power did not bring the King immense happiness is his decrepit statue. His message to the world is ironic in itself. Look on my works, Ye mighty, and despair!/Nothing beside remains . (11-12) Perhaps Ozymandias can be taken two ways. One way could be a threat to anyone who dares to claim themselves the king of kings . (10) Ozymandias perhaps was stating to those men Look at my success. No one can ever surpass this success! The irony is that Ozymandias success is now nothing. Nothing remains but his words. The face of his statue is broken, just like his legacy. Or perhaps Ozymandias statement is one everyone should head. Perhaps he is saying, Look at what my success has become: nothing. Despair mortals, for earthly success is always nothingness. Ozymandias message could be the moral for his story. Because only his words remain, and nothing but, people should take in his advice. Power and prestige does not equate fame or prosperity. Another important example of how earthly riches bring nothing is in Thomas Hardys The Convergence of the Twain3. Because he starts his poem with Lines on the Loss of the Titanic (1)4, it immediately tells the reader what to expect. His firsts stanza tells of the ship now, how it sits calmly at the bottom of the ocean, .. deep from human vanity. (3) He implies that the only escape from power and riches is by lying unnoticed at the bottom of the ocean. Throughout the poem, Hardy goes back and forth between the materialistic, high-class society that boarded the ship and those that house themselves there now. Over the mirrors meant/To glass the opulent/The sea-worm crawls (8-10) is one example of this. The mirrors, once golden and glowing with the faces of rich, beautiful men and women, now reflect the ugliness of the undersea world. Even the ornate jewelry that this society adorned themselves with have become nothing more than homes for sea algae. Jewels in joy designed/to ravish lie lightless, all their sparkle bleared and black and blind. (11-13) Those jewels are no longer the shining, glimmering trimmings of a wealthy society. They now are blurry, blackened spheres of a time long passed. Hardy prepares for us a rhetorical question, and one that proves to be the most important line of the entire piece: What does this vaingloriousness down here?'

Major Medical Center Case Study

Red flags raised in the opinion letter External auditors play the role in providing independent opinion on the true and fair view of the financial statements of an organization. Reflectively, â€Å"an auditor’s opinion can either be unqualified, qualified, adverse, or disclaimer† (Finkler 2010, p. 25). The opinions are arrived at after reviewing the financial statements of the organization. The reviews are carried out on a sample basis.Advertising We will write a custom report sample on Major Medical Center Case Study specifically for you for only $16.05 $11/page Learn More It reviews the standards applied when preparing the financial statements. The auditors have the opinion that financial statements of an organization, the results of the operations, changes in net assets and cash flows presented fairly in all material, respects the true financial position of the company. They further give the view that the statements are in conformity wit h the GAAP. Despite the favorable comments, the auditors do not give a straight unqualified opinion on the true and fair view of the financial position of the organization though there are no major concerns raised in opinion letter. This could raise concern on the financial condition of the organization (Finkler, 2010). Review of the financial statements Upon review of the statement of the financial position, it was observed that the Center had amount due from the third part reimbursement program amounting to $6,539,000 in 2012. This amount was not present in 2011. Further, long term investment increased from $618,000 to $1,132,000. Further, the amount of accrued salaries and accrued expenses increased from $20,096,000 to $25,572,000. Further, inventory and pledges receivable declined by close to 50%. These are major areas of concern. Review of statement of the operation reveals that there was a decline in the amount of interest expense from $5,253,000 to $4,456,000 despite the incr ease in the amount of long term debt. Further, increase in unrestricted net assets increased from $897,000 to $2,568,000. In the cash flow statement, operating income increased from $751,000 in 2011 to $2,429,000 to 2012. Review of notes to financial statement In general, notes to financial statements is expected to provide details of amounts reported in the financial reports. The notes also â€Å"give additional information on amounts that are not reported in the financial statements† (Finkler 2010, p. 31). The notes to financial statements does not give detailed explanations on significant changes in the financial statements highlighted above.Advertising Looking for report on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More For instance, the notes on third party reimbursement programs does not give details and a breakdown of the amount involved I the program. On property, plant and equipment, the notes do not give details of the amount of depreciation for each category of assets. Also, the notes to financial statements do not give details of the amount in excess of $1,900,000. This could create an indication of fraud. The notes did not provide the makeup of other income amounting to $731,000 in 2012 and $1,566,000 in 2011. Finally, the notes to financial statements do not provide an estimation of the amount of contingent liability from the litigation cases. It is necessary to have such information to enable he organization plan adequately for the loss (Finkler, 2010). Analysis of financial status The common size financial statements revealed some areas which require some in depth investigation. Examples of the items that require investigation are receivables for government grants, the amount due to third-party reimbursement programs, net assets released from restrictions, operating income and increases in unrestricted net assets. These areas changed significantly from 2011 to 2012. A review of these balances needs to be done so as to ensure that the changes can be supported (Finkler, 2010). Liquidity ratios or the company were relatively favorable. Both current and quick ratios were greater than one. This implies that the institution is in a position to pay the current obligation using current assets. However, the liquidity position of the company declined from 2011 to 2012. The efficiency ratios for the company are relatively fair. For instance, accounts receivable turnover increase from 7.76 to 8.10. Fixed asset turnover ranged between 4.12 and 4.09. Total asset turnover ranged between 2.10 and 2.05. Considering the nature of the organization, the level of activity of the organization is fairly high. Times interest earned ratio shows the ability of the organization to pay for the cost of borrowing funds using earnings before interest and taxes. Times interest earned ratio for the two years is less than one. This implies that the Center cannot pay for the interest exp ense. However, the value increased from 0.14 to 0.55.Advertising We will write a custom report sample on Major Medical Center Case Study specifically for you for only $16.05 $11/page Learn More It gives a bad indication to potential debt providers. Profitability of the Center is relatively low. The total margin of the institution ranged between 1.88% and 5.17%. Return on assets were quite low at 0.51% and 1.31%. Also, return on net assets ranged between 0.92% and 2.5%. It is evident that the profitability of the institution increased between 2011 and 2012. The low profitability can be attributed to the fact that the medical center is not a profit making institution. Therefore, it is evident that ratio analysis gives an in depth view of the financial statement of the center (Eugene Michael, 2009). References Eugene, B., Michael, J. (2009). Financial management theory and practice. USA: South-Western Cengage Learning. Finkler, A. (2010). Financial manag ement for public, health, and not-for-profit organizations. Upper Saddle River, NJ: Pearson Prentice Hall. This report on Major Medical Center Case Study was written and submitted by user Haiden Y. to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Essay Enzyme Carbohydrate and Biolsci 210 ‐b

Essay Enzyme Carbohydrate and Biolsci 210 †b Essay Enzyme: Carbohydrate and Biolsci 210 †b Enzymes: How can antibodies be used to treat cocaine overdoses? What cocaine? Proteins are chains of aminoisacids An alkaloid metabolite found in the leaves of Erythroxylon coca Blocks removal of dopamine from synapses in the reward pathway of the central nervous system BiolSci 210†B | 1/28/13 | 2 Cocaine is of amino our bodies by hydrolysis Proteins are chains degraded inacids Hydrolysis of cocaine yields two biologically inactive products +H2O BiolSci 210†B | 1/28/13 | 3 (Bio)chemical reactions progress through transition states (TS) Proteins are chains of amino acids BiolSci 210†B | 1/28/13 | 4 Transition chains of amino acids Proteins are states are often different from reactant and products How is cocaine different from its transition state in hydrolysis? Transition state analog (TSA) BiolSci 210†B | 1/28/13 | 5 Proteins are chains ofWhat are acids amino antibodies? Antibody (Ab) is a large Y†shaped protein produced by B†cells that is used by the immune system to identify and neutralize foreign objects Antibody recognizes a unique part of the foreign target, called an antigen Is this a tertiary or quaternary structure? BiolSci 210†B | 1/28/13 | 6 Production of chains of amino acids Proteins areantibodies can be induced by injection of specific antigens immunize with antigen obtain antibody specific for antigen BiolSci 210†B | 1/28/13 | 7 Discussion: How do antibodies help Proteins are chains of amino acidsprevent cocaine overdose? immunize with cocaine challenge with excess cocaine dies from overdose immunize with cocaine TSA challenge with excess cocaine survives 5 min BiolSci 210†B | 1/28/13 | 8 Stabilization of transition state leads Proteins are chains of amino acids to lower activation energy BiolSci 210†B | 1/28/13 | 9 Enzymes catalyzes reactions by binding to and stabilizing TS Proteins are chains of amino acids BiolSci 210†B | 1/28/13 | 10 Enzymes are highly specific Proteins are chains of amino acids catalysts Enzyme = a protein (or RNA) that catalyzes a specific chemical reaction Catalyst = enhances reaction rate without being consumed in the reaction BiolSci 210†B | 1/28/13 | 11 Proteins are chainsMost drugs inhibit enzymes of amino acids FDA orange book 1278 chemical entities approved for therapeutic use in the US 317 drugs act as enzyme inhibitors 78 target enzymes human 48 bacterial 13 viral 5 fungal 4 protozoal 1 fda.gov/cder/orange/obreadme.htm When the first print edition of Approved Drug Products with Therapeutic Equivalence Evaluations was being prepared October 1980, staff members had to choose a color for the cover. The project manager suggested, â€Å"It's almost Halloween. How about orange?† BiolSci 210†B | 1/28/13 | 12 Enzyme inhibitors are among Proteins are chains of amino acids the top 20 drugs Prescribed 1. Lipitor 2. Zocor 6. Nexium 11. Celebrex 17. Pravachol 20. Prevacid Enzyme Target HMG†CoA reductase HMG†CoA reductase Proton pump Cyclooxygenase 2 (COX†2) HMG†CoA reductase Proton pump 2004 sales $10.9 billion $5.2 billion $3.9 billion $3.3 billion $2.6 billion $2.6 billion COX†1 and COX†2 100,000 tons Over†the†counter Aspirin ~30% of approved drugs are enzyme inhibitors Understanding principles of enzyme inhibition has practical consequences BiolSci 210†B | 1/28/13 | 13 HIV of amino acids Proteins are chains maturation requires proteases HIV proteins are made as polyproteins, which are then processed by HIV protease to form individual, functional proteins BiolSci 210†B | 1/28/13 | 14 ProteinsDiscussion: How do HIV protease inhibitors function? are chains of amino acids 5 min Indinavir Amprenavir Saquinavir Ritonavir Nelfinavir BiolSci 210†B | 1/28/13 | 15